U.S. Marshal Teddy Daniels and his partner Chuck Aule begin to fear for their own lives and sanity when their investigation on Shutter Island into how a patient escaped the Ashcliffe Hospital for the Criminally Insane yields more questions than answers.
Investigating the murder of a Louvre curator, Harvard symbologist Robert Langdon and French cryptologist Sophie Neveu find clues painted into a Da Vinci work, inadvertently uncovering a plot involving the Holy Grail and the secret society known as the Priory of Sion.