A poor old tailor, dismayed when illness keeps him from finishing an important coat and vest for the Mayor of Gloucester, gets a little help from some nimble fingered mice.
Mouse Mistress Hildegarde musters all her ingenuity to keep a large colony of church mice safe from the exterminator and to see that they make it through the dangerous Blessing of the Animals.
Doctor De Soto, a mouse dentist, copes with the toothaches of various animals except those who have a taste for mice, until the day a fox comes to him in great pain.
Sam, a shy but creative mouse who lives in a library, decides to write and illustrate his own stories which he places on the shelves with the other library books but when children find the tales, they all want to meet the author.